AC Superactivation may partially explain the mechanism behind opioid-induced hyperaglesia. This figure represents the process graphically. In A) Morphine (M) activates the 7-transmembrane opioid receptor coupled to Gi, that inhibits adenylyl cyclase (AC). In B) AC superactivation exists when even after morphine no longer acts on the opioid receptor, AC remains active, cAMP levels are increased, and PKA is active.
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